[17]. Chinese drug Lianhua Qingwen is one of 3 treatments which are part of Chinas standard therapy for mild and moderate coronavirus patients. In addition, only studies published in English and Chinese will be searched and included because of language barriers, so a language bias may exist. WebChronic obstructive pulmonary disease (COPD) is characterized by a chronic inflammatory response that is worsened by acute exacerbations. You may search for similar articles that contain these same keywords or you may For the treatment of influenza due to heat-toxic attack lung, syndrome see: fever or serious fever,aversion to cold, muscle soreness, stuffy nose, runny nose, cough, headache, throat dry and sore throat, red tongue, yellow or yellow greasy tongue coating and so on. 2 capsules per dose. 3.Patients with common cold due to wind-cold dont apply to the product. China's top respiratory expert,the leader of the high-level expert group of the National Health Commission, Zhong Nanshan said in a webinar with overseas Chinese students, Lianhua Qingwen capsule has been proven effective for the treatment of virus. Wang Y, Zhang D, Du G, et al. Guyatt GH, Oxman AD, Vist GE, et al. [14]. [29]. Web[Strength] 0.35g/capsule [Administration and Dosage] For oral administration, 4 capsules once, 3 times daily [Adverse Reactions] Unclear [Contraindications] Unclear [Precautions] 1. Lianhua Qingwen capsule (granule) is an Innovative Patent Chinese medicine for the treatment of influenza, which was developed by the green channel of the new drug approval during the SARS period in 2003 based on the pathology of collateral of traditional Chinese medicine. The findings of the trial showed strong indications of LHQW in helping patients recover faster and in the prevention of severe covid disease, when compared to the control group using only standard treatment. In 2005, Diagnosis and Treatment Scheme for Patients Infected with Avian Influenza (2005), issued by the Ministry of Health, Famous Kazakhstan journalist talks about Lianhua, New Progress in Study on Mechanism of Lianhua Qingwen Capsules for Treatment of COVID-19, TCM (Traditional Chinese Medicine) received by Cambodia for treating COVID-19 patients. Please try after some time. The Philippines Food and Drug Administration (FDA) has approved the traditional Chinese medicine (TCM) capsule Lianhua Qingwen widely used in China as Traditional Chinese medicine Lianhua Qingwen treating corona virus disease 2019(COVID-19): Meta-analysis of randomized controlled trials. 8600 Rockville Pike 2022 Jan;20(1):26-33. doi: 10.1016/j.joim.2021.10.005. When the dose was administered at 150, 300, and 600 g/mL, it significantly inhibited the expression of SARS-CoV-2 in a dose-dependent manner, and inhibited the formation of plaques in virus-infected cells, confirming that Lianhua Qingwen significantly inhibited SARS-CoV-2 activity in vitro. It is not necessary for ethical approval because this article is based on previously conducted studies and does not involve any new studies of human or animal subjects performed by any of the authors. Effect of Lianhuaqingwen Capsule on lung index of mice infected with virus [J]. COVID-19; Lianhua Qingwen; clinical symptoms; retrospective study; total effective rate; traditional Chinese medicine (TCM) treatment. [Contraindications]Those who are allergic to this product and its ingredients should not take it. The Grading of Recommendations Assessment, Development, and Evaluation (GRADE) methodology[32] will be used to assess the quality of the evidence and risk of bias with on-line GRADE (https://www.gradeworkinggroup.org/). Avoid cigarettes, alcohol and keep from eating spicy, raw, cold or greasy food. WebLianhua Qingwen Dosage & Drug Information | MIMS Thailand Lianhua Qingwen(Forsythiae fructus 225 mg, Lonicerae japonicae flos 225 mg, Ephedrae herba 7. The site is secure. Ephedrine isanamphetamine-like compound, which is an addictive stimulant of the central nervous system. DC and QZ developed the search strategy. To add, theonline sale and distribution ofthis productis prohibited and those engaging in this activityviolatethe R.A.10918orPhilippine Pharmacy Act. It is used for temporary relief of shortness of breath, chest tightness, and wheezing due to bronchial asthma. [30] The I2 statistic of <50% indicates a low level of statistical heterogeneity, and that of 50% will be considered substantial statistical heterogeneity. Click to view Lianhua Qingwen detailed prescribing information Overdosage View Lianhua Qingwen For RCTs, the Cochrane Collaboration's tool for assessing risk of bias will be used; 2. We first used Rhubarb to cure the disease, dredge the internal organs and relieve the heat, and then made Huoxiang fragrant and moistening. Zhao Liu, Fuzhong Shi, zhanqiu Yang. and transmitted securely. Zhong said that, according to the experiment,the Lianhua Qingwen Jiaonang capsule can weakly inhibit the virus and repair cell injuries and inflammation caused by the virus. Pharmacological experiments have indicated that a high dosage of Lianhua Qingwen alters the effectiveness of cyclooxygenase-2 in the arachidonic acid metabolic pathway and Conclusion: Hongying Mo, Changwen Ke, Jinping Zheng, et al. Bioinform Biol Insights. Federal government websites often end in .gov or .mil. Particularly, when ephedrine is combined with caffeine (coffee), itcan lead to significant cardiovascular, metabolic, and hormonal responses. National Key New Product Medicine (Baltimore). [15]. As stated in the research paper published on "Scientific World Journal", Lianhua-Qingwen capsule (LQC) is a commonly used Chinese medical preparation to treat virus and especially played a very important role in the fight against severe acute respiratory syndrome (S-A-R-S) in 2002-2003 in China. XLZ and JNL will assess the risk of bias and perform data synthesis. Results: Removes heat-toxin invasion of the lungs, including symptoms eg, fever, aversion to cold, muscle soreness, stuffy & runny nose. Writing original draft: Xiaolin Zhang, Di Cao. Zhang, Xiaolin MDa,; Cao, Di MMb; Liu, Junnan MMa,c; Zhang, Qi MDa; Liu, Mingjun PhDa,, aChangchun University of Chinese Medicine. 2022 Aug 19;27(16):5292. doi: 10.3390/molecules27165292. The research results revealed that Lianhua Qingwen Capsules effectively improved the total effective rate of COVID-19 treatment, as it significantly ameliorated the symptoms of cough, fever and fatigue of patients, improved the disappearance rate of main symptoms, and shortened the duration of main symptoms on the basis of routine treatment. [35]. The product should beprescribed by a physician with a PDEA S-2 license. Avoid spicy & greasy food during medication. The 3 drugs and 3 parties in China have been effective in many countries around the world, and once again reveal the special advantages of the Chinese herbal medicine overall adjustment and multi target therapy, which suggests the application of Lianhua Qingwen granule. N Engl J Med 2020;382:92936. It is compatible with Rhodiola to clear lung and remove blood stasis. [18]. Clinical observation shows that the total effective rate of traditional Chinese medicine is >90%.[15]. The Bile Acid Membrane Receptor TGR5 in Cancer: Friend or Foe. The study was financially supported by the National Natural Science Foundation of China (Grant Number 86174092) and a grant from the School construction project of State Administration of traditional Chinese medicine (Grant Number LPGZS22014-11). Since all the data included are published, the systematic review does not need ethical approval. Buy Search for Similar Articles Led by Iloilos most respected journalists, the Daily Guardian pledges to tell the Ilonggo story as seen through the various lenses of society so that every side may be told. Before the evaluation results of this system are published, all databases will be retrieved again. To clear scourge and remove toxin, diffuse the lung and discharge heat. In 2019, Diagnosis and Treatment Scheme for Influenza (2019), issued by the National Health Commission LHQWG was first used in the treatment of influenza, and studies have found that the drug is superior to oseltamivir in improving the symptoms of influenza A virus infection. Whether a fixed-effects or a random-effects model will be used depends on the results of I2 test for heterogeneity. Patients diagnosed with COVID-19 of all ages and racial groups will be included. Among the many commonly used TCMs, the most commonly used one is Lian-Hua Qing-Wen Granule (LHQWG). Experimental study on the prevention and treatment of FM1 infected mice by Lianhuaqingwen capsule [J]. Nguyen HT, Do VM, Phan TT, Nguyen Huynh DT. The FDA had earlier put out an advisory in May warning against the purchase of unregistered versions of the Lianhua Qingwen Jiaonang capsule which had different labels. Designed by ACTSmarket. If I2 test 50%, a random-effects model will be used for data analysis instead. This study will provide a relatively high-quality synthesis of current evidence of Lianhua Qingwen combined with Conventional antiviral Western Medicine in the treatment of COVID-19 from several aspects including the Clinical effective rate, CT improvement rate, severe conversion rate, antipyretic time, disappearance rate of fever symptoms, Because the epidemic situation is still ongoing, there are still clinical studies in progress. Chinese Journal of viral diseases 2015;5:3524. There are no comments yet. BMJ 2003;327:55760. The following data will then be extracted from the studies selected for inclusion using a data collection form, and recorded onto an Excel file: first author and year, study design, sample, intervention, type of measures, risk of bias assessment, and findings. JAMA Intern Med 2020;March 13 (Epub ahead of print). Therefore, it is essential to perform a systematic review and meta-analysis to assess the effect of Lianhua Qingwen combined with conventional antiviral Western Medicine in clinical treatment of COVID-19 or asymptomatic infection. Published by Wolters Kluwer Health, Inc. 1. general information: title, authors, year of publication, and Study area, average age, average course of disease and treatment time; 2. trial characteristics: design, duration of follow-up, method of randomization, allocation concealment, incomplete outcome data, blinding (patients, people administering treatment, outcome assessors); 3. intervention(s): intervention(s) (The dosage form of. In 2013, Expert Consensus on Medical Treatment for Patients Infected with H7N9 Avian Influenza (2013), issued by the National Health and Family Planning Commission We plan to carry out the following subgroup analyses if possible: the study area is different, the average course of disease is different, and the length of treatment is different. 13. The registered Chinese capsule Lianhua Qingwen that has been approved should have the FDAs labeling requirements written in English, Domingo said. Not suitable for long-term use. BMJ 2008;336:9246. [23]. After determining how to combine different types of studies, NRIs use the method of inverse variance of random-effect model to evaluate and calculate the 95% CI of the effect value. [59] In the early stage, there is no specific medicine or vaccine; the intervention of Chinese traditional medicine compound Lianhua Qingwen and other traditional Chinese medicine have played an important role. Remdesivir in adults with severe, [13]. The composition of Lianhua Qingwen granules is consistent with the pathogenesis of the disease. XLZ conceived of the study, and perform this review. A statistically significant difference was identified between the Lianhua Qingwen group and the conventional drug group (OR=3.02, 95% CI=1.23 to 7.42, P=0.016). Pulmonary Imaging Improvement. Five studies reported improvement in pulmonary imaging. The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). Domingo said this version of the capsule was still unregistered to date, meaning the FDA could not guarantee its quality and safety. Novel coronavirus pneumonia is a new method for the treatment of new crown pneumonia. (4) intervention characteristics: Lianhua Qingwen in the treatment group (dosage form, dose, frequency, duration). There are an increasing number of studies on for COVID-19 published with inconclusive results in recent. WebLianhua Qingwen Jiaonang with Chinese Characters; As per continuing post-marketing surveillance, there is still incessant sale and distribution even through social media platforms, such as Facebook, of Lianhua Qingwen Jiaonang with Chinese characters, which were verified as unregistered by the FDA. Subgroup analysis and sensitivity analysis will be performed to explore the causes of heterogeneity. High-tech Demonstration Project of National Development and Reform Commission China's top respiratory expert, the leader of the high-level expert group of the National Health Commission, Zhong Nanshan said in a webinar with overseas Chinese students, Lianhua Qingwen capsule has been proven effective for the treatment of virus. Bookshelf Shunya Zhu, Xiaoying Li, Yunling Wei, et al. COVID-19; Lianhua Qingwen; meta-analysis; protocol; systematic review. Hai Guo, Jin Yang, Jiening Gong, et al. eCollection 2023. Effect of Lianhuaqingwen Capsule on lung pathological injury and expression of inflammatory factors in mice induced by automobile exhaust [J]. MJL will arbitrate any disagreement and ensure that no errors occur during the review. 2020 Jul 24;99(30):e21404. In China, lianhua qingwen is recommended for treating thepneumonia. BackgroundLHQW's formulation is based on two ancient formulae from the Han and Qing dynasties - Maxing Shigan decoction and Yinqiao powder - following the SARS epidemic. Copyright Shijiazhuang Yiling Pharmaceutical Co,Ltd. The .gov means its official. How to cite this article: Zhang X, Cao D, Liu J, Zhang Q, Liu M. Efficacy and safety of Lianhua Qingwen combined with conventional antiviral Western Medicine in the treatment of coronavirus disease (covid-19) in 2019: Protocol for a systematic review and meta-analysis. https://news.cgtn.com/news/2020-04-16/Beijing-approves-TCM-drugs-for-COVID-19-PJWgGfRAQg/index.html. Teresa May Bandiola is a licensed pharmacist, a published writer, and a university instructor. Before 11. [3] It is reported that 4,430,100 cases have been confirmed in the world, and 299,451 cases have died. Second, CT scan result also shows that patients recover faster than the control group. How to Use: Dosage: Consume orally 4 capsules each, 3 times daily after meal. Wenwen Cui, Xin Jin, Yanfen Zhang, et al. V03AX - Other therapeutic products ; Other products with therapeutic properties. Chinese herbal medicine 2008;31:12303. Sofia Tomacruz covers defense and foreign affairs. The abstracts of all studies will be independently screened by the review authors (XLZand QL). SHIJIAZHUANG YILING PHARMACEUTICAL CO., LTD. Lianhua Qingwen, a representative TCM patent product for the treatment of influenza. Consultancy by Fixx Digital [33] Previous pharmacodynamic studies have confirmed that Lianhua Qingwen capsule can significantly inhibit the SARS CoV virus in cultured cells in vitro, and has a significant inhibitory effect on H1N1, H3N2, h7n9, and other influenza viruses,[3436] indicating that Lianhua Qingwen capsule has played an important role in the prevention and control of public health events of respiratory system caused by virus. Dosage: 2 capsules twice a day ( after breakfast & dinner). Should not be used for wind-cold common cold. We may also contact the original authors to provide additional relevant information, if necessary. The Chinese prescription lianhuaqingwen capsule exerts anti-influenza activity through the inhibition of viral propagation and impacts immune function[J]. If you are using other drugs, please consult your doctor before using this product. PRISMA flow diagram of study and exclusion. FDA Phase-II Clinical Study, In 2020, Diagnosis and Treatment Scheme for Novel Coronavirus Pneumonia, jointly issued by the Chinese Health Protection Committee and the State Administration of Traditional Chinese Medicine (For Children 4 to 18 years of age): 3 times daily. An official website of the United States government. In addition, Manual retrieval of articles, conference papers, ongoing experiments, internal reports, among others, to supplement electronic retrieval. Recently, the novel coronavirus pneumonia (COVID-19) epidemic has spread continuously and has been classified as class B infectious diseases (class a management). Higgins JPT, Thompson SG, Deeks JJ, et al. https://en.prnasia.com/releases/global/tcm-lianhua-qingwen-shows-stable-in-vitro-antiviral-effect-on-the-delta-variant-expert-327965.shtml, Lianhua Qingwen Jiangnan (LHQW) for Flu and Colds. The authors have no conflicts of interest to disclose. Do not give during pregnancy & lactation, & in childn. In 2010, Diagnosis and Treatment Scheme for Wind-warm Lung-heat Disease (Non-severe Community Acquired Pneumonia) (2010), issued by the Chinese Health Protection Committee and the State Administration of Traditional Chinese Medicine [32]. V03AX - Other therapeutic products ; Other products with therapeutic properties. It is reported that the registration number of Lianhua Qingwen Capsules in the Philippines is THPR-50 and the product category is traditional herbal drugs. The Philippines Food and Drug Administration (FDA) has approved the traditional Chinese medicine (TCM) capsule Lianhua Qingwen widely used in China as part of its standard coronavirus treatments. Available at: [30]. The course of treatment is 7-10 days for patients with mild and moderate COVID-19. 8.Three days without any remission,or symptems aggravated,appeared new serious symptems, should go to hospital. Risk ratio (RR) was used to express the severe conversion rate and CT improvement rate absorption rate; mean difference (MD) was used to express the time of fever reduction in secondary indexes; Odds Ratio (OR) was used to express clinical efficiency and symptom disappearance rate. CT images of patient Mr. Lin (Male, Fifty-five years old) during different treatment periods. Kupferschmidt K, Cohen J. Buy two get one free promotion. The DDB, however, had no objections to the product registration ofLHQWwith the Philippine FDA and said that the importer or distributor shall secure the proper license from thePhilippine Drug Enforcement Agency (PDEA) and comply with all regulatory requirements and relevant issuances. Third, the capsule can shorten fever & coughting time. The novel coronavirus pneumonia (COVID-19) has spread to >200 countries and regions. Xiaoyan Liu. 2023 Jan 12;17:11779322221149622. doi: 10.1177/11779322221149622. In 2014, Diagnosis and Treatment Scheme for Patients Infected with H7N9 Avian Influenza (2014), issued by the National Health and Family Planning Commission A: CT at admission (February 14, 2020); B: CT Reexamination after treatment (February 25, 2020); C: CT Reexamination after treatment (March 13, 2020); D: CT Reexamination after discharge (June 11, 2020). This product should not be used in treatment of wind-cold. Lianhua Qingwen was developed by Shijiazhuang Yiling Pharmaceutical in 2003 as a treatment for severe acute respiratory syndrome (SARS) following the outbreak of the disease in 2002 and was listed by the National Health Commission of China in 2004 as a treatment for influenza and other respiratory disease.
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